Liver cirrhosis is a dangerous disease constantly progressing up to the complete impossibility of liver functioning. The disease is characterized by the death of liver cells (hepatocytes).
There are several reasons for the development of liver cirrhosis:
Hepatitis virus B, C, or D is the cause of virus-related liver cirrhosis. Chronic hepatitis C progresses to cirrhosis in most cases. What is viral hepatitis? Viral hepatitis is a chronic infectious disease developing when patients contract hepatitis virus B, C, or D. Moreover, B and C type viruses cause the disease in isolation, and D type virus – only with the help B type virus. These viruses can be contracted from infected individuals or carriers through their blood (cuts, punctures, blood transfusions, non-sterile household objects or medical devices, sexually, during childbirth from mother to child, etc.).
Virus-related cirrhosis develops as a result of the negative effect of the virus on liver cells – inflammatory and autoimmune responses. Hepatitis B virus itself does not have a toxic effect on hepatocytes (liver cells). When the virus reaches the liver via the bloodstream, it starts multiplying and triggering mutations in hepatocytes. Human body treats the liver cells as alien cells and tries to destroy them. The dead cells of the liver are replaced by connective tissue (fibrosis), which in itself damages normal liver cells even more, numerous necrosis foci develop (cirrhosis). In addition to the growth of connective tissue, hepatitis C and D have a toxic effect on the liver, which accelerates the progression of cirrhosis.
The liver is responsible for processing almost all alcohol entering the human body. At the same time, ethyl alcohol damages the liver cells, fibrosis develops (minor scarring, which leads to the impossibility of organ functioning in due mode of operation), and the latter in turn progresses to cirrhosis. Typically, in cases of alcohol abuse the process of organ damage develops slowly, compared, for example, to the virus-related liver cirrhosis. Yet, it inevitably leads to liver cirrhosis.
Often, pain in the liver is the first sign of virus-related liver cirrhosis. Yet, most people may remain unaware of the disease for many years. And although the final diagnosis of alcohol-related liver disease or virus-related liver cirrhosis can only be made by a hepatologist, there are signs typical for people suffering from this disease.
Symptoms of cirrhosis:
The accurate diagnosis and stage of cirrhosis can be determined only by a healthcare professional upon required laboratory and ultrasound diagnostics with liver elastometry. There are several stages of the disease, which differ in the degree of damages to the liver tissue.
In cases of viral hepatitis B, HBsAg, HBeAg, HBV DNA, and DNA polymerase are found in the blood. In this case, HBV DNA is a method for determination of the viral activity degree (HBV DNA count of more than 200 ng/L is indicative of increased activity, which can cause cirrhosis, therefore, treatment is required, the objective of the treatment is to reduce viral activity, to bring it to the so-called dormancy). Viral hepatitis C has the following markers: HBcAg, anti-HCV, HBV RNA. Viral hepatitis D is characterized by the presence of HDV RNA and anti-HDV in the blood.
Simultaneously, the patient is prescribed an ultrasound examination of the liver with elastometry, which allows determining the presence and stage of liver cirrhosis and prescribing certain treatment not only for the hepatitis virus, but also for regeneration of liver cells.
Alcohol-related liver cirrhosis can be diagnosed by elastometry or liver biopsy.
are the average life expectancy of patients with cirrhosis from the moment of diagnosis establishment providing the absence of proper treatment
of patients die from liver cirrhosis every year
in the world among diseases leading to death at the age of 35 to 60 years
are the average life expectancy in case of liver transplantation, but not therapeutic liver restoration
Therapy waiting time
2 to 5 years.
treatment starts immediately
Treatment injury for the patient
safe, painless, non-traumatic
Treatment injury for the member of a donor family
no need for donor
deterioration of the life quality, lifelong intake of immunosuppressants, increased risk of death due to viral, respiratory diseases.
Life expectancy after treatment
5 to 7 years.
within the lifespan of a healthy person
Benefits of treatment
therapy without work discontinuation, continuous improvement in the quality of life, relatively low-cost therapy
EUR 70,000 to 350,000.
hugely less, compared to transplantation and life-long maintenance after surgery; depends on the necessary number of courses
Appointment for the initial consultation by a hepatologist
Consultation, diagnostics of the cirrhosis cause, determination of the liver cirrhosis stage
After receiving the results of examination, a personal regimen is prescribed for the treatment of cirrhosis and, if necessary, treatment of concomitant diseases, e.g. alcohol dependence (detoxification is carried out), viral hepatits etc. Methods of cirrhosis treatment applied in the REHENERATSIIA Clinic allow not only to stop cirrhosis progression, but also to restore liver cells
Regular monitoring of the treatment dynamics, if necessary, adjustment of the treatment regimen. Management of the patient until positive outcome